Neuronal effects of acute citalopram detected by pharmacoMRI
In terms of the GSH/GPx4 pathway, both UC and CD patients show reduced GPx4 activity in the intestinal epithelial cells during active disease, suggesting a close association between IBD and ferroptosis [262, 276]
Figure S6
Attractive targets include members of the LOX family, namely LOX and LOX-like 2 (LOXL2), which mediate collagen and/or elastin crosslinking [97, 98], thereby contributing to ECM remodeling in the tumor microenvironment
The co-administration with cytochrome P450 2D6 (CYP2D6) inhibitors may also increase the risk with increased exposure to the active metabolite of VYVANSE (dextroamphetamine)
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